147657-22-5：產(chǎn)品說明書

147657-22-5：產(chǎn)品說明書

                                                <a href="https://www.medchemexpress.com/Calcipotriol-monohydrate.html">Calcipotriol (monohydrate)</a>產(chǎn)品描述：Calcipotriol monohydrate is a synthetic VitD3 analogue with a high affinity for the <b>vitamin D</b> receptor.IC50 &amp; Target: vitamin D receptor^[1]<i><b>In Vitro:</b></i> When NHEK cells are not stimulated with IL-17A or IL-22, Calcipotriol slightly enhances (0.2 nM) IL-8 mRNA expression or has no effect (2-20 nM). The addition of IL-17A and IL-22 markedly increased the mRNA expression of IL-8, confirming our previous study. This enhanced IL-8 mRNA expression is suppressed by Calcipotriol at 2, 20 and 40 nM in a dose dependent manner^[1]. Treatment of natural killer (NK) cells with drugs modulates their expression of NK cytotoxicity receptors or KIR. Human NK cells are pre-treated with 100, 10 or 1 ng/mL of 1,25(OH)₂D₃, Calcipotriol or FTY720 for 4 h. All three concentrations of 1,25(OH)₂D₃, Calcipotriol and FTY720 significantly up-regulate the expression of NKp30 on the surface of NK cells after 4 h incubation^{[2<br /><br /><br /><span    style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);">公司介紹：MedChemExpress(MCE)專注于各種抑制劑、激動(dòng)劑、API及化合物庫(kù)，總部位于美國(guó)新澤西，分別在瑞典和上海設(shè)有歐洲區(qū)子公司和亞洲區(qū)總代理，營(yíng)銷網(wǎng)點(diǎn)遍及全球20多個(gè)國(guó)家地區(qū)。MCE經(jīng)過多年努力已成為全球生物活性小分子領(lǐng)域的一流供應(yīng)商， 產(chǎn)品涵蓋癌癥、神經(jīng)科學(xué)、抗感染、表觀遺傳學(xué)等20個(gè)熱門研究領(lǐng)域，PI3K、MAPK等近千個(gè)細(xì)分靶點(diǎn)，超過4000個(gè)活性小分子化合物現(xiàn)貨，以及GPCR、API、離子通道等超過20種不同類型的化合物庫(kù)，同時(shí)提供從毫克到千克的專業(yè)定制合成服務(wù)。</span><br    style="color: rgb(62,62,62);" /><span    style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);">MCE 對(duì)每批產(chǎn)品都進(jìn)行嚴(yán)格的LCMS和NMR檢驗(yàn)，其產(chǎn)品已被全球近萬名客戶廣泛使用并發(fā)表大量文章、專利；</span><br    style="color: rgb(62,62,62);" /><span    style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);">MCE 定期增加各領(lǐng)域熱門抑制劑、激動(dòng)劑，不斷擴(kuò)增已有化合物庫(kù)，以滿足最新的科研需求；</span><br    style="color: rgb(62,62,62);" /><span    style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);">數(shù)千種產(chǎn)品在上海有充足備貨，24-48小時(shí)內(nèi)送達(dá)客戶；</span><br    style="color: rgb(62,62,62);" /><span    style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);">大量產(chǎn)品提供免費(fèi)試用裝；</span><span    style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);">已為全球多個(gè)知名企業(yè)、院校構(gòu)建各種定制型化合物庫(kù)。</span><br /><br />產(chǎn)品鏈接：<a    href="http://www.medchemexpress.cn/calcipotriol-monohydrate.html">www.medchemexpress.cn/calcipotriol-monohydrate.html</a><br /><br /><img    alt=""    src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg" style="width: 600.0px;height: 310.0px;" />}                                            </div>