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Ro 41-1049 (hydrochloride)

發(fā)布日期:2017-10-26   瀏覽次數(shù):0
核心提示:a href=https://www.medchemexpress.com/Ro-41-1049-hydrochloride.htmlRo 41-1049 (hydrochloride)/a產(chǎn)品描述:Ro 41-1049 hydr
<a href="https://www.medchemexpress.com/Ro-41-1049-hydrochloride.html">Ro 41-1049 (hydrochloride)</a>產(chǎn)品描述:Ro 41-1049 hydrochloride is a selective, reversible, orally-active MAO-A inhibitor.

Target: MAO

in vivo: Ro 41-1049 is an inhibitor of the enzyme monoamine oxidase type A (MAO-A) to rats and monitored extracellular catecholamine levels in the corpus striatum before and after the intraperitoneal (IP) administration of a bolus of L-dopa. Acute administration of Ro 41-1049 (1-50 mg/kg IP) produced a dose-dependent decrease in basal levels of the dopamine metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) and an increase in basal levels of dopamine. In rats treated with Ro 41-1049 (20 mg/kg IP), L-dopa administration (100 mg/kg IP) produced a greater increase in striatal levels of dopamine than it did in controls, while DOPAC and HVA formation was attenuated. We conclude that inhibition of central MAO-A activity promotes synaptic accumulation of dopamine following administration of pharmacological doses of L-dopa.<br><br>
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已為全球多個(gè)知名企業(yè)、院校構(gòu)建各種定制型化合物庫(kù)。</span><br><br>產(chǎn)品鏈接:<a href="http://www.medchemexpress.cn/ro-41-1049-hydrochloride.html">www.medchemexpress.cn/ro-41-1049-hydrochloride.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

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