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SQ22536

發(fā)布日期：2017-10-26   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/SQ22536.htmlSQ22536/a產(chǎn)品描述：SQ22536 is an effective badenylate cyclase/b (bAC/b
<a href="https://www.medchemexpress.com/SQ22536.html">SQ22536</a>產(chǎn)品描述：SQ22536 is an effective <b>adenylate cyclase</b> (<b>AC</b>) inhibitor.

IC50 & Target: adenylate cyclase (AC)<sup>[1]</sup>

<i><b>In Vitro:</b></i> SQ22536 (SQ22,536) effectively inhibits the effect of forskolin with respective IC<sub>50</sub> values of 5 μM.Preincubation with graded concentrations of SQ22536 reveals that both SQ22536 effectively inhibits PACAP-induced reporter gene activation with approximate IC<sub>50</sub> value of 5 μM. SQ22536 more potently inhibits forskolin-induced Elk activation (IC<sub>50</sub>=10 μM) than 8-Br-cAMP-induced Elk activation (IC<sub>50</sub>=170 μM). Most notably, there are substantial differences in the reported potencies of SQ22536 to inhibit the activities of recombinant AC5 and AC6, with respective IC<sub>50</sub> values of 2 μM and 360 μM. At a greater concentration (500 μM), SQ22536 significantly inhibits neurite elongation due to either forskolin or 8-Br-cAMP<sup>[1]</sup>.

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<span style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial , sans-serif;font-size: 11.818182px;background-color: rgb(251,251,251);">公司介紹：MedChemExpress(MCE)專注于各種抑制劑、激動(dòng)劑、API及化合物庫，總部位于美國新澤西，分別在瑞典和上海設(shè)有歐洲區(qū)子公司和亞洲區(qū)總代理，營銷網(wǎng)點(diǎn)遍及全球20多個(gè)國家地區(qū)。MCE經(jīng)過多年努力已成為全球生物活性小分子領(lǐng)域的一流供應(yīng)商， 產(chǎn)品涵蓋癌癥、神經(jīng)科學(xué)、抗感染、表觀遺傳學(xué)等20個(gè)熱門研究領(lǐng)域，PI3K、MAPK等近千個(gè)細(xì)分靶點(diǎn)，超過4000個(gè)活性小分子化合物現(xiàn)貨，以及GPCR、API、離子通道等超過20種不同類型的化合物庫，同時(shí)提供從毫克到千克的專業(yè)定制合成服務(wù)。</span>
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已為全球多個(gè)知名企業(yè)、院校構(gòu)建各種定制型化合物庫。</span><br><br>產(chǎn)品鏈接：<a href="http://www.medchemexpress.cn/sq22536.html">www.medchemexpress.cn/sq22536.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"

alt="">
 
 
 
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