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GC376

發(fā)布日期：2017-10-26   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/GC376.htmlGC376/a產(chǎn)品描述：GC376 is a b3CLpro/b inhibitor; inhibits the replicatio
<a href="https://www.medchemexpress.com/GC376.html">GC376</a>產(chǎn)品描述：GC376 is a <b>3CLpro</b> inhibitor; inhibits the replication of viruses TGEV, FIPV and PTV with <b>IC<sub>50</sub></b> values of 0.15, 0.2 and 0.15 μM.

IC50 & Target: IC50: 0.15 μM (TGEV), 0.2 μM (FIPV), 0.15 μM (PTV), 0.15 μM (229E), 1.1 μM (MHV), 5.3 μM (MNV-1), 0.6 μM (BCV)<sup>[1]</sup>

<i><b>In Vitro:</b></i> GC376 covalently binds to Cys 139, Cys 147, and Cys 144 of NV 3CLpro, PV 3Cpro, and TGEV 3CLpro, respectively. GC376 is significantly effective against caliciviruses (NV and MNV-1), coronaviruses (TGEV, FIPV, MHV, 229E, and BCV), and picornaviruses (HRVs 18, 51, and 68, EV71, and PTV), with nanomolar or low micromolar IC<sub>50</sub>s, except for FCV and HAV. Interestingly, FCV is less sensitive to GC376, with IC<sub>50</sub> of 35 μM. GC376 shows no or weak effectiveness against the replication of HAV in cells<sup>[1]</sup>. Proteases from NV, MD145 or MNV-1 are inhibited by GC376 with a similar potency. The IC<sub>50</sub> values of GC376 against 3CLpro from NV, MD145, a<br><br>
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<span style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial , sans-serif;font-size: 11.818182px;background-color: rgb(251,251,251);">公司介紹：MedChemExpress(MCE)專注于各種抑制劑、激動(dòng)劑、API及化合物庫(kù)，總部位于美國(guó)新澤西，分別在瑞典和上海設(shè)有歐洲區(qū)子公司和亞洲區(qū)總代理，營(yíng)銷網(wǎng)點(diǎn)遍及全球20多個(gè)國(guó)家地區(qū)。MCE經(jīng)過(guò)多年努力已成為全球生物活性小分子領(lǐng)域的一流供應(yīng)商， 產(chǎn)品涵蓋癌癥、神經(jīng)科學(xué)、抗感染、表觀遺傳學(xué)等20個(gè)熱門研究領(lǐng)域，PI3K、MAPK等近千個(gè)細(xì)分靶點(diǎn)，超過(guò)4000個(gè)活性小分子化合物現(xiàn)貨，以及GPCR、API、離子通道等超過(guò)20種不同類型的化合物庫(kù)，同時(shí)提供從毫克到千克的專業(yè)定制合成服務(wù)。</span>
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已為全球多個(gè)知名企業(yè)、院校構(gòu)建各種定制型化合物庫(kù)。</span><br><br>產(chǎn)品鏈接：<a href="http://www.medchemexpress.cn/gc376.html">www.medchemexpress.cn/gc376.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

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