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Triapine研究進(jìn)展

發(fā)布日期：2017-10-27   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/Triapine.htmlTriapine/a產(chǎn)品描述：Triapine is a novel inhibitor of the M2 subunit o
<a href="https://www.medchemexpress.com/Triapine.html">Triapine</a>產(chǎn)品描述：Triapine is a novel inhibitor of the M2 subunit of <b>ribonucleotide reductase</b> (<b>RR</b>), and is a potent radiosensitizer.

IC50 & Target: Ribonucleotide reductase (RR)<sup>[1]</sup>

<i><b>In Vitro:</b></i> Triapine is a potent derivative of α-heterocyclic carboxaldehyde thiosemicarbazone (HCT) that inhibits hRRM2 and p53R2 isoforms of the M2 subunit<sup>[1]</sup>. Triapine is thought to inhibit ribonucleotide reductase through its preformed iron chelate, rather than directly by removing iron from the active site. In cells containing less topoisomerase IIα fewer DNA strand breaks will be produced, and thus topoisomerase II poisons will be less inhibitory in the K/VP.5 cell line. The IC<sub>50</sub>s for Dp44mT growth inhibition are 48±9 nM and 60±12 nM, for K562 and K/VP.5 cells, respectively. The IC<sub>50</sub>s for Triapine growth inhibition are 476±39 nM and 661±69 nM for K562 and K/VP.5 cells, respectively<sup>[2]</sup>. PKIH and DpT Fe chelators show high antiproliferati<br><br>
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已為全球多個(gè)知名企業(yè)、院校構(gòu)建各種定制型化合物庫(kù)。</span><br><br>產(chǎn)品鏈接：<a href="http://www.medchemexpress.cn/triapine.html">www.medchemexpress.cn/triapine.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"

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