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Q203研究進(jìn)展

發(fā)布日期：2017-10-27   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/Q203.htmlQ203/a產(chǎn)品描述：Q203 (IAP6) is a midazopyridine amide compound. Q203 is a
<a href="https://www.medchemexpress.com/Q203.html">Q203</a>產(chǎn)品描述：Q203 (IAP6) is a midazopyridine amide compound. Q203 is active against <i>Mycobacterium tuberculosis</i> H37Rv with an <b>MIC<sub>50</sub></b> of 2.7 nM in culture broth medium.

IC50 & Target: MIC50: 2.7 nM (<i>Mycobacterium tuberculosis</i> H37Rv)<sup>[1]</sup>

<i><b>In Vitro:</b></i> Imidazopyridine amide (IPA) compounds block <i>Mycobacterium tuberculosis</i> growth by targeting the respiratory cytochrome bc1 complex. The optimized IPA compound Q203 inhibits the growth of MDR and XDR <i>Mycobacterium tuberculosis</i> clinical isolates in culture broth medium in the low nanomolar range. Q203 is active against the reference strain <i>Mycobacterium tuberculosis</i> H37Rv with <b>MIC<sub>50</sub></b>s of 2.7 nM in culture broth medium and 0.28 nM inside macrophages<sup>[1]</sup>.

<i><b>In Vivo:</b></i> Q203 is efficacious in a mouse model of tuberculosis at a dose less than 1 mg per kg body weight. Q203 displays pharmacokinetic and safety profiles compatible with once-daily dosing. <br><br>
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已為全球多個知名企業(yè)、院校構(gòu)建各種定制型化合物庫。</span><br><br>產(chǎn)品鏈接：<a href="http://www.medchemexpress.cn/q203.html">www.medchemexpress.cn/q203.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"

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