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Iberdomide研究進(jìn)展

發(fā)布日期：2017-10-27   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/Iberdomide.htmlIberdomide/a產(chǎn)品描述：Iberdomide (CC-220) is a cereblon modulator i
<a href="https://www.medchemexpress.com/Iberdomide.html">Iberdomide</a>產(chǎn)品描述：Iberdomide (CC-220) is a cereblon modulator in clinical development for systemic lupus erythematosis. Iberdomide exhibits an <b>IC<sub>50</sub></b> of 60 nM in TR-FRET cereblon binding assay.

<i><b>In Vitro:</b></i> Lenalidomide and pomalidomide, targeting cereblon, are immunomodulatory drugs that are clinically effective in the treatment of cancer, including newly diagnosed and relapsed multiple myeloma. Iberdomide contains a glutarimide ring that binds in the try-tryptophan pocket of cereblon and an isoindolinone ring that can interact with both cereblon and substrates. Treatment with Iberdomide results in the loss of Ikaros and Aiolos protein levels with EC<sub>50</sub>s of 1 nM and 0.5 nM <sup>[1]</sup>.



<i><b>In Vivo:</b></i> Iberdomide (CC-220) is currently in phase 2 clinical trials for the treatment of systematic lupus erythematosus (SLE) and phase 1b/2a clinical trials for relapsed and refractory multiple myeloma (MM)<sup>[1]</sup>.

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已為全球多個(gè)知名企業(yè)、院校構(gòu)建各種定制型化合物庫(kù)。</span><br><br>產(chǎn)品鏈接：<a href="http://www.medchemexpress.cn/iberdomide.html">www.medchemexpress.cn/iberdomide.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"

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