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RG14620研究進展

發(fā)布日期：2017-10-30   瀏覽次數(shù)：0
核心提示：a href=https://www.medchemexpress.com/RG14620.htmlRG14620/a產品描述：RG14620 is an epidermal growth factor receptor (bEG
<a href="https://www.medchemexpress.com/RG14620.html">RG14620</a>產品描述：RG14620 is an epidermal growth factor receptor (<b>EGFR</b>) inhibitor, with <b>IC<sub>50</sub></b> values of 3 μM for HER 14 colony formation and 1 pM for HER 14 DNA synthesis.

IC50 & Target: IC50: 3 μM (HER 14 colony formation); 1 pM (HER 14 DNA synthesis) <sup>[1]</sup>

<i><b>In Vitro:</b></i> RG-14620 inhibits colony formation and DNA synthesis by HER 14 cells, which are stimulated by 50 ng/mL EGF, in a dose-dependent manner. The IC<sub>50</sub>s for RG-14620 are 3 μM for HER 14 colony formation and 1 pM for HER 14 DNA synthesis<sup>[1]</sup>. RG-14620 also suppresses colony formation and DNA synthesis by EGF-stimulated MH-85 cells in a dose-dependent manner. The IC<sub>50</sub>s for RG-14620 on MH-85 cells are 4 μM for colony formation and 1.25 μM for DNA synthesis<sup>[1]</sup>.



<i><b>In Vivo:</b></i> RG-14620, at a dose of 200 μg/mouse/day inhibits MH-85 tumor growth in nude mice. Mice show less cachexia and hypercalcemia, eat more food, and are more active than untreated <br><br>
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