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TAK-438 free base生物實(shí)驗(yàn)方法參考

發(fā)布日期:2017-11-23   瀏覽次數(shù):0
核心提示:產(chǎn)品名稱:ahref=http://www.medchemexpress.cn/TAK-438-free-base.htmlTAK-438freebase/a__TAK-438(freebase)是一種新型的鉀競
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產(chǎn)品名稱:<a href="http://www.medchemexpress.cn/TAK-438-free-base.html">TAK-438 free base</a>__TAK-438 (free base)是一種新型的鉀競爭性的酸阻斷劑,可逆抑制H+/K+,ATPase,IC50為19 nM (pH 6.5)。<BR>產(chǎn)品化學(xué)信息:Molecular Weight<br> 345.39<br> Formula<br>C??H??FN?O?S<br>CAS No.<br>881681-00-1<br>Storage<br>                                                        Powder                -20°C<br>                3 years                                        &nbsp;                4°C<br>                2 years                                        In solvent                -80°C<br>                6 months                                        &nbsp;                -20°C<br>                1 month                                                                                                                        Shipping<br>Room temperature in continental US; may vary elsewher<br>Solvent & Solubility<br>DMSO:  33 mg/mL<br><br>* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.<br>                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        [1]. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed/22512618">Arikawa Y, et al. Discovery of a novel pyrrole derivative 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate (TAK-438) as a potassium-competitive acid blocker (P-CAB). J Med Chem, 2012, 55(9), 4446-4456.</a><br>                                                  [2]. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed/20624992">Hori Y, et al. 1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438), a novel and potent potassium-competitive acid blocker for the treatment of acid-related diseases. J Pharmacol Exp Ther, 2010, 335(1), 231-238.</a><br>                                                  [3]. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed/21411494">Hori Y, et al. A study comparing the antisecretory effect of TAK-438, a novel potassium-competitive acid blocker, with lansoprazole in animals. J Pharmacol Exp Ther, 2011, 337(3), 797-804.</a><br><BR>實(shí)驗(yàn)方法參考:References<br/>          [1]. <a href="http://www.ncbi.nlm.nih.gov/pubmed/22512618" rel="nofollow" target="_blank">Arikawa Y, et al. Discovery of a novel pyrrole derivative 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate (TAK-438) as a potassium-competitive acid blocker (P-CAB). J Med Chem, 2012, 55(9), 4446-4456.</a><br>        [2]. <a href="http://www.ncbi.nlm.nih.gov/pubmed/20624992" rel="nofollow" target="_blank">Hori Y, et al. 1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438), a novel and potent potassium-competitive acid blocker for the treatment of acid-related diseases. J Pharmacol Exp Ther, 2010, 335(1), 231-238.</a><br>        [3]. <a href="http://www.ncbi.nlm.nih.gov/pubmed/21411494" rel="nofollow" target="_blank">Hori Y, et al. A study comparing the antisecretory effect of TAK-438, a novel potassium-competitive acid blocker, with lansoprazole in animals. J Pharmacol Exp Ther, 2011, 337(3), 797-804.</a><br><BR>產(chǎn)品研究領(lǐng)域:<a href="http://www.medchemexpress.cn/Pathways/Membrane Transporter_Ion Channel.html"><span>Membrane Transporter/Ion Channel</span></a><a href="http://www.medchemexpress.cn/Targets/Proton Pump.html"><span>Proton Pump</span></a><BR>TAK-438 free base相關(guān)產(chǎn)品<a href="http://www.medchemexpress.cn/TAK-438.html" target="_blank">TAK-438</a>&nbsp;&nbsp;|&nbsp;&nbsp;<a href="http://www.medchemexpress.cn/Omeprazole.html" target="_blank">Omeprazole</a>&nbsp;&nbsp;|&nbsp;&nbsp;<a href="http://www.medchemexpress.cn/Pantoprazole-sodium.html" target="_blank">Pantoprazole sodium</a>&nbsp;&nbsp;|&nbsp;&nbsp;<a href="http://www.medchemexpress.cn/_R_-Lansoprazole.html" target="_blank">(R)-Lansoprazole</a>&nbsp;&nbsp;|&nbsp;&nbsp;<a href="http://www.medchemexpress.cn/zinc-pyrithione.html" target="_blank">Zinc Pyrithione</a>&nbsp;&nbsp;|&nbsp;&nbsp;<a href="http://www.medchemexpress.cn/AZD0865.html" target="_blank">AZD0865</a>&nbsp;&nbsp;|&nbsp;&nbsp;<a href="http://www.medchemexpress.cn/Ilaprazole.html" target="_blank">Ilaprazole</a>&nbsp;&nbsp;|&nbsp;&nbsp;<a href="http://www.medchemexpress.cn/esomeprazole-magnesium-trihydrate.html" target="_blank">Esomeprazole Magnesium trihydrate</a>&nbsp;&nbsp;|&nbsp;&nbsp;<a href="http://www.medchemexpress.cn/Bamaquimast.html" target="_blank">Bamaquimast</a>&nbsp;&nbsp;|&nbsp;&nbsp;<a href="http://www.medchemexpress.cn/Rabeprazole-sodium.html" ta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