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Calycosin說明

發(fā)布日期:2018-04-23   瀏覽次數(shù):0
核心提示:毛蕊異黃酮 (Calycosin)是一抗氧化和抗炎癥活性天然化合物。
毛蕊異黃酮 (Calycosin)是一抗氧化和抗炎癥活性天然化合物。
Sodium phenylbutyrate產(chǎn)品描述:Sodium 4-phenylbutyrate(TriButyrate), a Histone deacetylase inhibitor, is terminal aromatic substituted fatty acid that has been used for the treatment of urea cycle disorders. IC50 Value: 1-5 uM [1] Target: HDAC in vitro: In comparison, the carboxylate histone deacetylase inhibitors sodium valproate, sodium butyrate, and 4-phenylbutyrate were less potent (IC50 range 1-5 uM) [1]. Treatment with sodium 4-phenylbutyrate, but not with glycerol or dimethylsulfoxide, reduced the amount of detergent-insoluble myocilin aggregates, diminished myocilin interaction with calreticulin, and restored the secretion of mutant myocilin. Sodium 4-phenylbutyrate treatment of cells coexpressing mutant and wild-type myocilin relieved ER stress and significantly reduced the rate of apoptosis. Treatment with 4-PB resulted in the significant in vitro and in vivo growth inhibition of pancreatic tumor cells. The reduction of the xenograft tumor volume was associated with the inhibition of histone deacetyla


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產(chǎn)品鏈接:www.medchemexpress.cn/Sodium-phenylbutyrate.html


Purity:98%
MWt:284.2635
Formula:C16H12O5
SMILES:O=C1C(C2=CC=C(OC)C(O)=C2)=COC3=CC(O)=CC=C13
Pathway:Others;
Mechanisms:Others;
Research Area:Cancer
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關(guān)鍵詞: Calycosin
 
 
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