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20633-67-4:產(chǎn)品說明書

發(fā)布日期:2017-10-25   瀏覽次數(shù):0
核心提示:20633-67-4:產(chǎn)品說明書 a href=https://www.medchemexpress.com/Calycosin-7-O-_beta_-D-glucoside.htmlCalycosin-7-O--D-gluco
20633-67-4:產(chǎn)品說明書

                                                Calycosin-7-O-β-D-glucoside產(chǎn)品描述:Calycosin-7-O-β-D-glucoside, a melanin biosynthesis inhibitor, is isolated from the methanol extract of astragalus. IC50 value: 68 μM in inhibition of Tyrosinase Target:In vitro: Calycosin-7-O-β-d-glucoside showed a melanin biosynthesis inhibition zone in a culture plate of Streptomyces bikiniensis. Furthermore, 75.78 μM of calycosin-7-O-β-d-glucoside dramatically decreased 50% of the melanin content on Melan-a cells without any apparent cytotoxicity [1]. Calycosin-7-O-β-D-glucoside was revealed to scavenge NO, inhibit the activities of MMP-2 and MMP-9, and attenuate cell death in the in vitro cultured brain microvascular endothelial cells under OGD condition.In vivo: Calycosin-7-O-β-D-glucoside treatment significantly reduced infarct volume, histological damage and blood–brain barrier permeability in the in vivo MCAO ischemia–reperfusion rat model [2]. To reveal its physiological functions under stress, seedlings with different isoflavonoid levels were established using a phe


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