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ST-193研究進展

發(fā)布日期:2017-10-30   瀏覽次數(shù):0
核心提示:a href=https://www.medchemexpress.com/ST-193.htmlST-193/a產品描述:ST-193 is a potent broad-spectrum barenavirus/b inhib
<a href="https://www.medchemexpress.com/ST-193.html">ST-193</a>產品描述:ST-193 is a potent broad-spectrum <b>arenavirus</b> inhibitor; inhibits Guanarito, Junin, Lassa and Machupo virus with <b>IC<sub>50</sub></b> values of 0.44, 0.62, 1.4 and 3.1 nM, respectively.

IC50 & Target: IC50: 0.44 nM (Guanarito), 0.62 nM (Junin), 1.4 nM (Lassa) and 3.1 nM (Machupo)<sup>[1]</sup>

<i><b>In Vitro:</b></i> ST-193 inhibits LASV pseudotypes with an IC<sub>50</sub> of 1.6 nM. ST-193 inhibits pseudotypes generated with other arenavirus envelopes as well, including the remaining four commonly associated with hemorrhagic fever (IC<sub>50</sub>s for Junín, Machupo, Guanarito, and Sabiá were in the 0.2 to 12 nM range) but exhibits no antiviral activity against pseudotypes incorporating either the GP from the LASV-related arenavirus lymphocytic choriomeningitis virus or the unrelated G protein from vesicular stomatitis virus, at concentrations of up to 10 μM<sup>[2]</sup>.

<i><b>In Vivo:</b></i> ST-193 is found to be tolerated well when administered daily as an intraperi<br><br>
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已為全球多個知名企業(yè)、院校構建各種定制型化合物庫。</span><br><br>產品鏈接:<a href="http://www.medchemexpress.cn/st-193.html">www.medchemexpress.cn/st-193.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

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